Pure Hoodia Gordonii Weight Loss

VIVUS, Inc. (Nasdaq: VVUS), a pharmaceutical company dedicated to the development and commercialization of novel therapeutic products addressing obesity and sexual health, today announced that Dr. Kishore Gadde, principal investigator in the study and the Director of Obesity Clinical Trials at Duke University, presented positive results from a Phase 2 clinical trial of Qnexa(TM) (formerly VI-0521), an investigational oral treatment for obesity, at the North American Association for the Study of Obesity (NAASO) 2006 Annual Scientific Meeting. The NAASO Meeting is being held this week in Boston. When compared to those on placebo, patients treated with Qnexa experienced a statistically significant average weight loss and a reduction in waist circumference. Significant reductions were also seen in lipid levels despite normal mean baseline values. The dropout rate for the trial was 8% in the Qnexa arm, as compared to 38% for the placebo arm.

“Qnexa demonstrated significant weight loss and reduction in waist circumference in this study, coupled with excellent tolerability and a positive impact on certain factors pertaining to metabolic syndrome in obese patients,” commented Leland Wilson, president and chief executive officer of VIVUS. “This is the first time the Qnexa Phase 2 data has been presented in a medical forum and represents the beginning of our education process with practicing physicians on the potential of Qnexa.”

Dr. Gadde’s presentation, entitled A 24-week Randomized Controlled Trial of VI-0521, a Combination Weight Loss Therapy, in Obese Adults, provided data on average weight-loss, percent of weight loss from baseline, waist circumference and the observed benefit of Qnexa with respect to certain risk factors contributing to metabolic syndrome. Metabolic syndrome is a condition characterized by multiple metabolic risk factors, including obesity as well as elevated triglyceride levels, blood pressure and cholesterol. Dr. Gadde also detailed the primary findings from this study, which have been previously reported.

Presentation Highlights

Qnexa is a proprietary oral investigational pharmaceutical treatment for obesity. The Phase 2 study was a double-blind, randomized, placebo-controlled trial conducted at Duke University. This trial involved 200 subjects, 159 women and 41 men with an average age of 40 and a mean body mass index (BMI) of 38.6. (A BMI of > 30.0 is classified as obese per guidelines from the U.S. Department of Health and Human Services.)

Patients completing the twenty-four week treated period achieved a highly significant average weight loss of 26.0 pounds, as compared to 7.0 pounds for the placebo group (p < 0.0001). Using an intent-to-treat, last observation-carried forward (ITT-LOCF) analysis, treatment with Qnexa had a highly significant average weight loss of 25.1 pounds, compared to 4.8 pounds for the placebo group (p < 0.0001).

The study completion rate for patients on Qnexa over the 24-week treatment period was 92%, as compared to 62% for patients in the placebo group.

Additional Findings on Weight Loss

Patients completing the twenty-four week treatment period lost on average 11.1% of baseline body weight, as compared to an average 2.8% in the placebo group. The difference between the Qnexa arm and the placebo arm was highly significant (p < 0.0001). Using an ITT-LOCF analysis, patients on Qnexa lost 10.7% of baseline body weight, as compared to 2.1% for the placebo arm (p < 0.0001). The primary efficacy endpoint for weight loss trials as required by the U.S. Food and Drug Administration is demonstration of a mean placebo-subtracted 1 year weight loss of greater than or equal to 5%. In Europe, The Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMEA) has recommended that demonstration of significant weight loss of at least 10% of baseline weight is considered to be a valid primary endpoint for anti-obesity drugs.

Using an ITT-LOCF analysis, the percentage of patients achieving 5%, 10% and 15% weight loss from baseline was 82% (p < 0.0001), 50% (p < 0.0001) and 20% (p=0.0007), respectively, as compared to 14%, 8% and 0% for the placebo group.

Findings for Secondary Endpoints

On an ITT-LOCF basis, patients in the Qnexa group had a significant reduction of waist circumference of 12.6 cm, as compared to 6.4 cm for the placebo group (p < 0.0001). Waistline is an indicator of central adiposity, which has been shown to be positively correlated with the risk factors for diabetes, cardiovascular disease and certain types of cancer.

Patients treated with Qnexa had a mean reduction of 10% for cholesterol and 16.2% for triglycerides, as compared to a reduction of 3.5% and an increase of 6.7%, respectively, for the placebo group. Baseline cholesterol and triglycerides were considered normal. Decreases in blood pressure as measured by the mean change from baseline at week 24 were also observed in the Qnexa group as compared to the placebo group. These findings suggest that Qnexa may improve certain metabolic risk factors in obese patients. Qnexa was well tolerated in this trial. Adverse events occurring in greater than 10% in the Qnexa arm as compared to placebo included paresthesia (mild tingling of the extremities), altered taste and increased urinary frequency. There were no dropouts in the Qnexa arm due to serious or severe adverse events.

About Qnexa

Qnexa is a proprietary pharmaceutical treatment that incorporates low doses of active ingredients from two previously approved products (phentermine and topiramate). By combining the activity of each of these compounds, Qnexa simultaneously addresses excessive appetite and high threshold for satiety, the two main mechanisms that impact eating behavior. We believe Qnexa is the first product to treat obesity in this manner. Qnexa is subject to U.S. and International patents.

About Obesity

In 2004, the U.S. Centers for Disease Control and Prevention ranked obesity as the number one health threat in America. Obesity is a chronic condition that affects millions of people and often requires long-term or invasive treatment to promote and sustain weight loss. Obesity is the second leading cause of preventable death in the United States. The American Obesity Association estimates that approximately 127 million, or 64.5 percent of adults in the U.S. are overweight, and an estimated 60 million, or 30.5 percent, are obese. The total direct and indirect costs attributed to those who are overweight and obese amounted to $117 billion in 2000. Additionally, Americans spend more than $33 billion annually on weight-loss products and services.

About Metabolic Syndrome

According to the American Heart Association, “The metabolic syndrome is characterized by a group of metabolic risk factors in one person.” Such factors include but are not limited to:

– Abdominal obesity
– Blood fat disorders that foster plaque buildup in artery walls including:
– high triglycerides
– low HDL cholesterol
– high LDL cholesterol
– Elevated blood pressure

People with metabolic syndrome have an increased risk of coronary heart disease and other conditions that result from the buildup of plaque in artery walls (e.g., stroke and peripheral vascular disease) and type 2 diabetes. It is currently estimated that more than 50 million Americans are living with metabolic syndrome.

About VIVUS

VIVUS, Inc. is a pharmaceutical company dedicated to the development and commercialization of next-generation therapeutic products addressing obesity and sexual health. VIVUS has three products that are positioned to enter Phase 3 clinical trials, and one product currently under NDA review by the FDA. The pipeline includes: Qnexa(TM), for which a Phase 2 study has been completed for the treatment of obesity; Testosterone MDTS(R), for which a Phase 2 study has been completed for the treatment of Hypoactive Sexual Desire Disorder (HSDD); EvaMist(TM), for which a Phase 3 study has been completed and an NDA submitted for the treatment of menopausal symptoms; and avanafil, for which a Phase 2 study has been completed for the treatment of erectile dysfunction (ED). MUSE(R) is approved and currently on the market for the treatment of ED. For more information on clinical trials and products, please visit the company’s web site at http://www.vivus.com/.

Certain statements in this press release are forward-looking within the meaning of the Private Securities Litigation Reform Act of 1995. These statements may be identified by the use of forward-looking words such as “anticipate,” “believe,” “forecast,” “estimated” and “intend,” among others. These forward-looking statements are based on VIVUS’ current expectations and actual results could differ materially. There are a number of factors that could cause actual events to differ materially from those indicated by such forward-looking statements. These factors include, but are not limited to, substantial competition; uncertainties of patent protection and litigation; uncertainties of government or third party payer reimbursement; reliance on sole source suppliers; limited sales and marketing efforts and dependence upon third parties; risks related to the development of innovative products; and risks related to failure to obtain FDA clearances or approvals and noncompliance with FDA regulations. As with any pharmaceutical under development, there are significant risks in the development, regulatory approval and commercialization of new products. There are no guarantees that future clinical studies discussed in this press release will be completed or successful or that any product will receive regulatory approval for any indication or prove to be commercially successful. VIVUS does not undertake an obligation to update or revise any forward-looking statement. Investors should read the risk factors set forth in VIVUS’ Form 10-K for the year ended December 31, 2005 and periodic reports filed with the Securities and Exchange Commission.

There are some websites on the Internet, which promise you that you are going to lose 10 pounds in every 2 weeks. If you are good in math you will find that keeping these stats in mind, 260 pounds in a year. Losing 260 pounds is the figure, which is unbelievable and unexpected.

This kind of claims are planned just to cause clients to make impulsive decisions. When you gain weight, did you gained around 50 pounds in two months? Certainly not. We gain weight in small parts, which add up to our weight. This keeps on increasing with time.

So how can you expect this weight to go in few days? You are going to lose the way you have gained it. So it will take time to lose weight. So you have to start losing weight systematically. You can lose weight by developing the good eating habits in you and nutritious foods.

It also helps to have a good diet supplement such as hoodia to go along with everything.

This is your 8 month advance warning people!

The sun is up, the heat pours down and summer is finally here. With the winter and spring behind us, it’s once more the time of skirts, T-shirts, tank tops and shorts. People can finally go out without having to burden themselves with a lot of clothes and without having to endure the cold. The beach days are about to begin. Love, fun and beauty are in the air. It’s now time to take a good look at yourself and ask the big question: are you prepared for the summer? Eating too much food and skipping regular exercises is a sure way of ruining your looks ahead of the most important time of the year. Are you ready to go shopping for a new bikini suit because the one you already have doesn’t fit anymore?

But you don’t have to go through this. As people start showing off their bodies and having fun under the summer sun, you too can join them without feeling embarrassed or ashamed. You don’t think that’s possible? Then try ProShape rx, the best and fastest answer to your problems. This amazing weight loss solution contains Hoodia Gordonii, the magic African plant that has the dieting market gaping in wonder at the power of suppressing hunger pangs. What could be better than forgetting that you have to eat with no side effects whatsoever? Are you having a hard time sticking to a diet because of the nagging feeling of hunger? Join the growing crowd of ProShape rx users and make hunger a thing of the past.

There is no reason why you should have to hide your body and forgo all the fun pastimes. With the help of ProShape rx you can go biking, swimming, skating and skateboarding knowing that you look great and that you can proudly display your body wherever you feel like it. All these summer pastimes actually help you burn existing fat faster, while ProShape rx makes sure that your body does not store calories as new fat. Moreover, this excellent product helps you endure even more effort than before, as the Beet Root extract clears your blood of toxins and strengthens your cardiovascular system.

Diets come a dime a dozen and that’s the truth. From food plans based on scientific research, to the latest harebrained idea launched by some “this summer’s wonder” doctor and backed by the earnest efforts of Hollywood stars always on the quest for keeping thin, the world is full of diets. The latest big thing to hit the dieting market is Hoodia Gordonii, an African plant that has the astonishing property of curing hunger pangs. A bit of Hoodia and you can go on without eating for days and be no worse for the wear. It’s amazing things like these that make the dieting world interesting.

What most diets and dieting professionals are good for is to pronounce solemnly “Don’t eat this” or “Don’t eat that”. Talk being extremely cheap for the one who does the talking, it can nevertheless be made expensive for those ready to do the hearing. Always be careful about what diets let you eat and what they don’t. Diet or no diet, your body needs certain nutrients and minerals on a daily basis and any diet that keeps you from getting them is no good. Your mind also needs to blow off steam once in a while. So do yourself a pleasure and eat a forbidden food every now and then. Sure it’s banned, but you are also human and, if such things are kept on a careful check, then they won’t make any difference in the long run.

The second pillar of any good diet is exercise. The only way to lose weight without exercising is by resorting to surgery. Otherwise, fat must be lost the natural way: by using it up through extra effort. Exercising has the combined benefits of burning up fat and strengthening your entire body. On the physical side, the heart and circulatory system are the prime beneficiaries of exercising, with the muscle mass coming in second. On the psychological side, your outlook on life and your mood will improve with the effort. You will also be able to withstand stress and pressure better. With so many benefits, it’s a wonder that many people don’t take the trouble to exercises on a regular basis.

This is why we are proposing you a combination of herbal pills and exercises that is practically guaranteed to help you shed those excess pounds fast. The ProShape rx pills are 100 percent natural and contain the powerful ingredients Hoodia, which curbs the feeling of hunger, White Kidney Bean, for disrupting the conversion of starch to sugar, Chitosan, which prevents the absorption of cholesterol and White Willow, to metabolize fat. These ingredients and the comprehensive program of exercises will have you reach your target weight in no time at all. Order ProShape rx today and make the first step toward a healthier life.

Regardless of how sad or cynical this may sound, truth is we’re living in a world that has always used looks to hastily judge a person instead of waiting for actions to be performed and thoughts to be voiced. The world is not a fair place. Those who look better get to enjoy more perks and amenities than others. They get asked out and invited to nice parties. They rise faster to the top because everyone, men and women, likes to see a pretty face and a shapely body around. Smart people can still climb the social and professional ladder, but it’s far easier for somebody who got lucky at birth and came into the world with a fair face and a body, or someone who works hard to keep in shape and be at a good weight, to die for.

First impressions are crucial. Today, we meet more and more people and trust less and less of them. Socializing and work put us in contact with persons from other parts of our towns, other cities or other countries. It’s a huge world and we get to know it on a personal basis by meeting a lot of people. That’s why we have to make a good first impression and the same goes for people who meet us. They are under the same pressure as we are. That’s why it really pays to look good. Looks can get one safely through a first meeting and if one can talk without putting one’s foot in one’s mouth, then success will be pretty easy to come by. The fools and the ugly will envy any such person, but that comes with the territory. I hate to be blunt, but being overweight in today’s society [b]IS UGLY[/b] and that looks negative in all facets of your life.

Don’t get me wrong. Most people are able to understand what others feel and what kind of heart others have, but the first impression, the one that sometimes makes or breaks a relationship. Everyone knows that what’s inside is what actually matters, but everyone relates first from the outside and that’s a fact. Looks can help friendships a lot and good looking people find it easier to spark a conversation with strangers. Also, people feel more at ease around a good looking person, which is why such people get high visibility jobs in the media and film industry. Fact is we all want to look good, regardless of how we feel inside. If you feel good and look good, good things will come to you. It’s a real simple statistical fact.

Dieting is not always easy. In fact, it can prove a tough challenge for many people. So here’s a little guide to avoiding things that could make you lose control and start eating. Avoid them like plague if you wish to succeed.

1. Don’t rush into the toughest diet you can find.
This is a frequent mistake. Many people decide in a moment of desperation to follow a super-strict diet and fail. Don’t rush into a diet that may be too strict for you. If you don’t have any dieting experience and are not 100 percent sure you can stick with the diet, then choose something else.

2. Don’t lose touch with reality.
You can’t realistically expect things to happen over night. When choosing your goal, start small, but be prepared to go far. If you hear someone saying that he lost a large number of pounds in a short time, don’t make it your goal to match his performance. Diet results are different from one person to another.

3. Don’t go to the gym too often
Another common mistake is to use the enthusiasm of the first days to hit the gym every day. This won’t help you at all. Your body needs time to heal and expand the muscle mass after each training session and going to the gym every day interferes with this natural process. Besides, a week of non-stop training could never offset ten or twenty years of couch potato lifestyle.

4. Don’t get hard on calories.
We all know that cutting down on calories is one of the building blocks of all diets, but you have to be careful about it. Cut down on too many calories and your body will start storing anything it possibly can. This is not a good way to lose weight.

5. Don’t skip meals!!!
Some people think that skipping one or two meals could help them lose weight faster. They don’t understand that dieting is all about eating the right food and not starving yourself. If you skip meals, your body STORES MORE FAT. This causes you to maintain weight. Skipping meals will not cause weight loss, EVER.

6. Don’t check the bathroom scales everyday.
Everybody is eager to see the confirmation of his or her efforts in the shape of lost pounds, but you should not let this drive you to checking your weight everyday. The daily fluctuations of your weight will soon have you depressed and ready to quit dieting. And this is something you want to avoid.

7. Don’t let emotions drive you.
Aside from the eagerness that drives people to check their weight every day, there are other emotions that influence dieting. If you know you’re used to reaching out for ice-cream or snacks when you are bored, frustrated or angry, then you should deal with these issues and not allow them to come between you and your purpose.

8. Don’t refuse to seek help.
Not everyone was born with iron will and nerves of steel. If you need advice or help, don’t hesitate to ask it from your friends or from professionals. Don’t try to solve all problems by yourself.

9. Don’t deny yourself your favourite foods.
Treats are a great way of raising your willpower and determination. Diets are just food control methods, not prisons. So what if you eat something forbidden once in a while, especially if that food is a favourite of yours? If such treats are not frequent, then they will make no difference in the long run.

10. Don’t rely on your willpower alone
Use your head as well. If you wish to know how much you eat, then write everything down and analyze the list for things that should not be there. Sometimes hunger creeps up on you and make you eat something you shouldn’t. Be honest with yourself and keep a clear head.

Introducing a plant from South Africa that has the weight-loss crowd thrilled. Is this the thing that could help millions of overweight people display bodies to die for? Maybe, just maybe, this is the magic pill we’ve all been waiting for.

Let’s face it, the onslaught of fashion magazines and shows has drummed the perfect shape of a fit body into everybody’s brains. We all know how we’re supposed to look like to be attractive and to give off that “carefree success” look. What we did not know is that the next big thing in dieting comes from South Africa

From the sandy expanses of the Kalahari Desert intrepid businessmen bring a cactus called Hoodia. Weight loss experts are already excited over the avenues opened by this plant that curbs hunger.

For hundreds of years the Kalahari bushmen have been eating Hoodia to keep hunger at bay during long hunting trips and in times of drought. And now millions of people living in industrialized countries are about to join them, as Hoodia-based pills are made available in the USA. However, for all the glittering promise of a better tomorrow, Hoodia is still somewhat of a problem. First, no scientific tests have been conducted on humans to check the effects of this plant. We know it works for the bushmen, but will it work for everybody just as well and without side effects?

People high and low, from Hollywood stars to high-powered entertainment staffers to the common man, everybody is willing to overlook the lack of official studies and have a go at Hoodia. Many people have been fighting excess weight all their lives and are interested in anything that promises fast and effective weight loss.

One of the latest and most effective drugs launched on the weight loss market is the ProShape RX! Does it have the amazing Hoodia among its ingredients? You bet! This new pill may well prove to be a ray of hope for overweight people looking to improve their looks and health by shedding those extra pounds. If Hoodia is really the magic plant all overweight people are waiting for, then ProShape RX is one of the best choices around.

I’ve always been overweight. Ever since I was a kid, I have always liked food and hated exercising. Staying at home in front of the TV, playing console games, or at the computer always seemed much more fun than going out. I’ve never been able to match the other guys in sports because I could not run fast enough, so I used to keep clear of outdoor games. Because of this, I had few friends and I was always unhappy with my life. I hated school and all those who made fun of me, especially since I could not afford to talk back to boys who could easily hurt me.

As the years passed, I gained more and more weight and spent more and more time indoors. My girlfriend dumped me, probably for a better looking guy, and my friends didn’t like to come around to my place any more than I liked going to theirs. That’s when I started thinking about losing weight through dieting. Despite the loneliness and fear of facing other people, I still refused to admit that something might be wrong with me. Dieting sounded interesting, but the idea of denying myself good food was appalling. One might say that I lived for eating at that time. That’s probably why my early attempts at dieting were complete failures.

When I first read about ProShaperx on the Internet I thought “There’s no way a pill can curb the feeling of hunger”. I was sure that the whole idea was a scam, but it had me thinking. The reason why I had always failed to stick to a diet was the strong feeling of hunger. So I figured that a pill that takes the hunger away could really help me. Later I saw the impressive list of signed testimonials featured on the ProShaperx website and I felt certain that ProShaperx could help me, too. I ordered my first supply of pills and it was a major turning point in my life. I knew that if I defeated my hunger I would really lose weight and I was right.

I have already lost a couple of pounds and I’m not going to quit. I’ve also started going to the gym and I feel ready to try my hand at socializing. I know that my socializing skills are practically zero, but I might as well start sooner than later. I have a long road before me, but I am committed and sure of myself. I think that overweight people should really consider letting ProShaperx help with the dreaded feeling of hunger. It certainly worked for me.

- Mick B.
Maryland

I wanted to let you know that Hoodia Rush is doing a: Buy 4 get 2 free promo. So you now get 6 bottles for the price of 4. This deal will go away soon.

Also, Hoodia Rush has a 100% money back guarantee now.

IS HOODIA THE NEW DIET PILL?

“Hoodia is unanimously recognized as the most effective natural substance ever discovered to safely aid weight loss.”

Dr. Richard Goldfarb thinks it works. He is the medical director of research and development at Bucks County Clinical Research. He says Hoodia isn’t a stimulant but it works on the brain.

Goldfarb: “It kind of fools the mind and body into – a feeling of fullness.”

There are several companies that sell hoodia online. They claim hoodia simply decreases your appetite, and if you’re not hungry, you’ll eat less. How much less you ask?

Goldfarb: “The appetite suppressant effect — after it accumulates in your system, after only a few days we saw in our study has shown that people will cut their calories probably in less than half and their not desiring any additional food.”

Goldfarb has done some research on hoodia — a small study admittedly by medical standards. In Goldfarb’s study of seven participants categorized as overweight, each participant was required to eat a balanced breakfast with a multivitamin in the morning. They took one capsule of pure hoodia with 8 ounces of water an hour before lunch, and repeated that an hour before dinner. They didn’t alter their dietary habits or activity levels.

“On average, they lost 10 pounds over the 28 day study. They reported no major side effects.” This was all without diet and exercise. Simply taking this small pill made from a rare cactus made them eat less. The whole experience is painless and easy. Admittedly many people have skepticism over the ability of a pill to reduce weight by that much… After all, if it sounds too good to be true it usually is. It seems nature, after all has found a way to reduce our hunger and ultimately our weight. Hoodia Gordonii isn’t a diet pill, it is THE pill. Harnessing the power of a simple plant from South Africa, people from all over the world can drastically reduce their weight and their quality of life.

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